cKO females do not ovulate.
A, morphology of ovaries and uteri from adult control and cKO females. B and C, ovary and uterus weights from 10-week-old control and cKO females (n = 12/genotype). D, day of vaginal opening in control and cKO females (n = 6/genotype). E, H&E-stained ovaries from representative 10-week-old control and cKO females. Corpora lutea (CL) are labeled. Scale bars, 100 μm. F, COCs collected after exogenous gonadotropin stimulation in juvenile control and cKO females (n = 18 or 7 for control and cKO, respectively).