FIGURE 5.

Ataxia and hypoalgesia in Δ10 mice. A, footprint test. Representative ink footprint patterns (left panel) revealed abnormal spreading of hind limbs for Δ10 mice (right panel). Gray lines on the left panel were drawn to measure footprint angles with regard to walking direction (three mice/genotype). B, grid test. When walking on a grid Δ10 mice slipped more often than WT mice (six mice/genotype). C, hanging wire test. The latency to fall down from the grid was significantly shorter for Δ10 mice than for WT mice (6–9 mice/genotype). D, grip strength analysis. The grip strength of Δ10 mice was similar to that of WT mice (7–9 mice/genotype). E, hot plate test. On a heated plate at 52 °C, paw withdrawal latency was increased for Δ10 mice compared with WT mice (7–9 mice/genotype). Data are means ± S.E. Statistical analyses: unpaired t test (A–C, **, p < 0.01; D, p = 0.4643, non significant; E, *, p < 0.05).