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. 2016 Dec 15;292(6):2441–2456. doi: 10.1074/jbc.M116.758029

FIGURE 7.

FIGURE 7.

Morphological alterations of PNS NR in Δ10 mice. A–C, representative immunostaining of sciatic nerves fibers from 14-month-old WT and Δ10 mice for nodal, paranodal, and juxtaparanodal proteins (four mice/genotype). A, Caspr1/Pnd (green) and Kv1.1 (red). B, NrCAM (green) and Nav (red). C, Nfasc186, Kv7.2, AnkG, βIV-spectrin (βIV) (green) and contactin/F3 (F3) (red). D, protein expression in sciatic nerves from 8-month-old WT and Δ10 mice evaluated by immunoblotting. Pnd, Caspr1/paranodin; Nfasc155/Nfasc186, 155/186-kDa isoforms of neurofascin; β3-tub, neuronal β-tubulin. Clathrin was used to normalize protein expression. Scale bars, 5 μm.