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. Author manuscript; available in PMC: 2018 Feb 13.
Published in final edited form as: Cancer Cell. 2017 Feb 13;31(2):286–299. doi: 10.1016/j.ccell.2017.01.006

Figure 2. Genomic characterization of paired chemonaive and chemoresistant SCLC PDX models.

Figure 2

(A) Mutational analysis of paired naive and resistant PDX models by whole exome sequencing. Shown are identifiable mutations by class among the most frequently mutated genes in primary SCLC (George et al., 2015).

(B) Analysis of mutational profiles and their associated COSMIC mutational signatures in two paired chemonaive and chemoresistant (-R) PDX models.

(C) Private versus shared mutations between paired chemonaive and chemoresistant PDX models. Colors indicate mutations variant allele frequencies (VAF) called as unique to the naive (grey) or resistant (red) tumor, with shared mutations in white.

(D) Copy number variation (CNV) in somatic chromosomes for paired chemonaive and chemoresistant models.

See also Figure S2.