. Author manuscript; available in PMC: 2018 Mar 1.

Published in final edited form as: Kidney Int. 2016 Dec 1;91(3):671–682. doi: 10.1016/j.kint.2016.09.042

Table 1.

Effect of podocin2.5-CCR2 expression after 9 weeks of STZ-induced diabetes.

Genotype	CCR2^+/−		CCR2^−/−		CCR2^−/− Tg(NPHS2-Ccr2)

Treatment	Control	Diabetes	Control	Diabetes	Control	Diabetes
Mice number	11	11	8	10	11	13
Body Weight (g)	30.69±0.71	21.61±0.84^a	29.19±0.98	21.43±1.02^a	29.28±0.63	19.84±0.79^a
Blood glucose (mg/dL)	144.7±4.98	499.1±0.25^a	149.6±7.85	483.6±15.5^a	150.1±4.14	497.7±1.40^a
SBP (mmHg)	111.4±2.4	118.3±2.3	121.1±3.9	117.5±3.0	114.2±2.8	116.8±2.2
KW/BW (g/100 g BW)	0.84±0.04	1.18±0.05^a	0.95±0.03	1.11±0.05^b	0.86±0.03	1.16±0.04^a
Average Glomerular Size (µm²)	20211±89	2305±81^b	2227±86	2350±68	2103±90	2595±103^a
BUN (mg/dL)	23.60±0.89	32.24±1.88^a	19.79±0.88	25.95±1.38^a,^c	20.65±0.88	32.21±1.10^a
Creatinine Clearance (ml/min)	0.12±0.04	0.05±0.02	0.12±0.08	0.11±0.03	0.12±0.05	0.04±0.02

Data are mean ± SEM.

: p<0.01 compared to control;

: p<0.05 compared to control;

: p<0.05 compared to diabetic Ccr2^+/− and diabetic Ccr2^−/− Tg(NPHS2-Ccr2) groups.

SBP: systolic blood pressure, KW/BW: kidney weight/body weight.