Table 5.
Multivariable-adjusted hazard ratios of mortality according to combined quartiles of CRP and FGF23.
| Total N | Deaths, N | HR (95%CI) | ||
|---|---|---|---|---|
| FGF23 Quartile 1 | CRP Quartile 1 | 299 | 15 | Reference |
| CRP Quartile 2 | 274 | 23 | 1.51 (0.77–2.99) | |
| CRP Quartile 3 | 208 | 26 | 2.19 (1.13–4.26) | |
| CRP Quartile 4 | 188 | 19 | 1.72 (0.84–3.53) | |
| FGF23 Quartile 2 | CRP Quartile 1 | 259 | 20 | 1.33 (0.67–2.66) |
| CRP Quartile 2 | 269 | 30 | 1.70 (0.88–3.26) | |
| CRP Quartile 3 | 257 | 30 | 1.95 (1.02–3.73) | |
| CRP Quartile 4 | 183 | 27 | 2.32 (1.19–4.51) | |
| FGF23 Quartile 3 | CRP Quartile 1 | 231 | 30 | 2.02 (1.05–3.87) |
| CRP Quartile 2 | 245 | 30 | 1.98 (1.03–3.82) | |
| CRP Quartile 3 | 243 | 41 | 2.85 (1.52–5.33) | |
| CRP Quartile 4 | 250 | 45 | 2.87 (1.54–5.36) | |
| FGF23 Quartile 4 | CRP Quartile 1 | 185 | 26 | 2.86 (1.45–5.65) |
| CRP Quartile 2 | 177 | 32 | 3.32 (1.71–6.43) | |
| CRP Quartile 3 | 261 | 57 | 3.36 (1.80–6.25) | |
| CRP Quartile 4 | 344 | 99 | 5.54 (3.04–10.09) |
Stratified by site and adjusted for age, sex, race, ethnicity, body mass index, diabetes, smoking status, history of CVD, systolic blood pressure, estimated glomerular filtration rate, urine albumin-to-creatinine ratio categories, serum albumin, hemoglobin, low-density lipoprotein; use of aspirin, beta blockers, statins and angiotensin-converting enzyme inhibitor or angiotensin II receptor blockers, active vitamin D, nutritional vitamin D, phosphate binders, and steroids; serum calcium, phosphate and parathyroid hormone.