(a) Western blot analysis and (b–h) densitometry quantification of PEDF, phosphorylated low-density lipoprotein receptor-related protein 6 (p-LRP6), total LRP6, non-phosphorylated β-catenin (non-p-β-catenin), total β-catenin, connective tissue growth factor (CTGF) and collagen III in kidney homogenates from 6 month-old db/db mice and wild-type (WT) controls (n=10). Each lane represents an individual mouse. &&p<0.01, db/db versus WT. All values are expressed as mean±SD.