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. Author manuscript; available in PMC: 2018 Feb 15.
Published in final edited form as: Cancer Res. 2016 Dec 9;77(4):949–959. doi: 10.1158/0008-5472.CAN-16-1731

Figure 7. Schematic representation of Ad. mda-7-induced cell death in cancer cells.

Figure 7

MDA-7/IL-24 down regulates miR-221 which in turn up regulates Beclin-1 to induce toxic autophagy and cell death in cancer cells. Additionally, the pathways that are regulated by mda-7/IL-24 are depicted here schematically.