Fig. 1.

Overview illustrating the pro-arrhythmic interactions between Ca²⁺-sensitive proteins, intercalated disk proteins and ion channels. SR sarcoplasmatic reticulum, RyR ryanodine receptor, SERCA SR Ca²⁺ ATPase, PLN phospholamban, LTCC L-type Ca²⁺ channel, NaL late sodium current, NCX Na⁺/Ca²⁺ exchanger, NKA Na⁺/K⁺-ATPase, AnkG ankyrin-G, DSC2/DSG2 desmocolin-2/desmoglein-2, PKP2 plakophilin-2, Cx43 connexin43, N-Cad N-Cadherin, CaMKII Ca²⁺/calmodulin-dependent protein kinase II, CaM calmodulin, CnA calcineurin A, EB-1 end-binding protein 1, NFAT nuclear factor of activated T‑cells, CACNA1D voltage-dependent L‑type calcium channel subunit alpha-1D, ATP2A2 sarcoplasmic/endoplasmic reticulum calcium ATPase 2, SCN5A sodium channel protein type 5 subunit alpha, Col1A1/1A2/3A1 alpha-1 type I/1 type 2/3 type 1 collagen, TGFβ1 transforming growth factor beta 1, CTGF connective tissue growth factor, TIMP1 metallopeptidase inhibitor 1