Table 1. Demographics and Clinical Data of Pre- and Post-LT Groups and HCs.
| Parameter | HCs (n = 25) | Pre-LT (n = 20) | Post-LT (n = 20) | P | ||
|---|---|---|---|---|---|---|
| Pre-LT/HCs | Post-LT/HCs | Post-/Pre-LT | ||||
| Sex (M/F) | 18/7 | 13/7 | 13/7 | 0.614* | 0.614* | - |
| Age (years) | 49.6 ± 8.3 | 51.9 ± 6.9 | 51.9 ± 6.9 | 0.316† | 0.316† | - |
| Education (years) | 12.6 ± 3.0 | 12.1 ± 4.1 | 12.1 ± 4.1 | 0.642† | 0.642† | - |
| NCT-A (seconds) | 44.1 ± 10.8 | 78.6 ± 33.8 | 59.2 ± 30.8 | 0.000† | 0.028† | 0.000‡ |
| DST (score) | 48.6 ± 10.4 | 27.8 ± 12.8 | 35.0 ± 14.0 | 0.000† | 0.001† | 0.000‡ |
| Biochemical parameters | ||||||
| Prothrombin time (seconds) | - | 17.9 ± 4.3 | 12.1 ± 2.6 | - | - | 0.000‡ |
| Albumin (mg/dL) | - | 29.6 ± 6.2 | 38.0 ± 5.8 | - | - | 0.000‡ |
| Total bilirubin (mg/dL) | - | 68.6 ± 54.9 | 21.7 ± 13.2 | - | - | 0.001‡ |
| Venous ammonia (μmol/L) | - | 71.6 ± 29.2 | 42.2 ± 13.8 | - | - | 0.000‡ |
| Child-Pugh B/C | - | 3/17 | - | - | - | - |
| No-HE/MHE/HE | - | 2/5/13 | - | - | - | - |
*Chi-square test, †Two-sample t test, ‡Paired two-sample t test. DST = digit-symbol test, HCs = healthy controls, HE = hepatic encephalopathy, LT = liver transplantation, MHE = minimal hepatic encephalopathy, NCT-A = number connection test-A