Table 1.

Summary of patient baseline sociodemographics, clinicopathological, and treatment characteristics of our esophageal adenocarcinoma discovery and validation cohorts

Variable	Subgroup	Discovery Cohort	Validation Cohort	P Value
Sociodemographic variables
Gender	Male	86%	85%	0.88
Age at diagnosis	Median (range)	64 (29–88)	62 (29–86)	0.08
Ethnicity	Caucasian	91%	91%	1.00
Occupation	White collar	54%	51%	0.72
Education	Any postsecondary	52%	50%	0.82
Marital status	Married or equivalent	72%	73%	0.80
BMI at diagnosis	Underweight (≤18.5)	4%	2%	0.49
	Overweight (>25)	48%	54%
Smoking status	Current	14%	29%	0.003
	Ex‐smoker	56%	43%
Pack years smoked	Median (range)	13.5 (0–118)	15 (0–180)	0.25
Alcohol use	Yes	86%	69%	< 0.001
Years drinking	Median (range)	41 (0–77)	29 (0–70)	< 0.001
Clinicopathological variables
Barrett's esophagus	Yes	19%	15%	0.34
Heart burn	Yes	78%	72%	0.27
H. pylori	Yes	4%	4%	1.00
ECOG	0/1+	21%/79%	22%/78%	0.89
Weight loss	Median (range)	5.4 (0–55.9)	5.4 (0–34.4)	0.36
Tumor location	GEJ	40%	39%	0.007
	Distal	50%	43%
	Middle	8%	2%
Clinical stage overall	1–3	66%	71%	0.33
	4	34%	29%
Overall treatment intent	Curative	78%	74%	0.44
Surgery attempted	Yes	69%	59%	0.07
Successful surgery	Yes	62%	53%	0.12
Radiation received	Yes	59%	60%	0.91
Chemotherapy	Adjuvant or NeoAdjuvant	46%	59%	0.02

All values represent percentages of patients except for pack years smoked, years of alcohol drunk, weight loss and age where the median and range in brackets are given. P values compare characteristics between the discovery and validation cohorts.

GEJ, gastro‐esophageal junction; ECOG, Eastern Cooperative Oncology Group performance score; BMI, body mass index.