Table 4.
Multivariate associations results between the miRNA pathway polymorphisms and overall survival in esophageal adenocarcinoma across all three esophageal adenocarcinoma cohorts (discovery, validation, and combined) among polymorphisms originally found to be significantly associated with overall survival in the discovery cohort
| Gene | RS Number | A1 | A2 | Discovery cohort results | Validation cohort results | Combined cohort results | |||
|---|---|---|---|---|---|---|---|---|---|
| aHR (95% CI) | P Value | aHR (95% CI) | P Value | aHR (95% CI) | P Value | ||||
| GEMIN3 | rs197412 | C | T | 1.37 (1.04–1.80) | 0.02 | 1.05 (0.72–1.54) | 0.80 | 1.19 (0.95–1.49) | 0.13 |
| hsa‐mir‐124‐1 | rs531564 | G | C | 0.60 (0.37–0.99) | 0.05 | 0.72 (0.47–1.11) | 0.13 | 0.72 (0.52–0.99) | 0.045 |
| KIAA0423 | rs1053667 | C | T | 0.51 (0.28–0.96) | 0.04 | 0.80 (0.34–1.86) | 0.60 | 0.56 (0.32–0.97) | 0.038 |
The multivariate analysis results were adjusted based upon the original model for the discovery cohort, which included weight loss, stage, and successful surgery.
A1, Minor Allele, A2, Major Allele. aHR are per each risk (minor) allele (A1).