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The establishment of TMZ‐resistant glioma cell lines. (A) The IC50 values of TMZ in six glioma cell lines. (B) The IC50 values of TMZ were markedly higher in TMZ‐resistant glioma cell lines than their parental cell lines. Results are reported as the mean ± SD of four independent experiments, ***P < 0.001. TMZ, temozolomide; SD, standard deviation.
