Table 1.
Multivariable cox regression model evaluating the association between CDKN2A nonpromoter methylation or expression and time to locoregional recurrence
| Variable | N | Hazard Ratio | 95% CI | P‐value |
|---|---|---|---|---|
| Methylated or high expression | ||||
| Negative | 25 | – | ||
| Positive | 41 | 0.21 | (0.05, 0.81) | 0.024 |
| Age | ||||
| <60 years old | 28 | – | ||
| ≥ 60 years old | 38 | 0.55 | (0.12, 2.44) | 0.430 |
| Gender | ||||
| Male | 48 | – | ||
| Female | 18 | 0.30 | (0.03, 2.76) | 0.290 |
| Nodal metastases | ||||
| N0 | 32 | – | ||
| N+ | 34 | 1.17 | (0.28, 4.89) | 0.830 |
| Treatment | ||||
| Unimodalitya | 28 | – | ||
| Surgery + adjuvantb | 25 | 1.48 | (0.27, 8,13) | 0.650 |
| Chemo‐radiation | 13 | 5.00 | (0.91, 27.43) | 0.064 |
Model stratified on institution (MMC or TCGA). Hazard ratios were mutually adjusted for all other variables shown.
a
Unimodality, radiation alone or surgery alone.
b
Adjuvant, postoperative radiation or chemoradiation.
“–”reference category.
CI, confidence interval.