Table 1. Demographics, clinical, behavioural and temperament measures for GS:SFHS individuals in the current study.
|
Controls (n=16 764)a |
MDD cases (n=2587)a |
Significance T/Chi2 (P-value) | |||
|---|---|---|---|---|---|
| Mean | s.d. | Mean | s.d. | ||
| Demographics | |||||
| Mean age (years)a | 47.61 | 15.27 | 46.36 | 12.88 | 15.73 (7.31 × 10−5) |
| Gender (M:F)a | 7218:9546 | — | 746:1841 | — | 186.54 (2.20 × 10−16) |
| Cognitive | |||||
| Logical memory (n=16 764;n=2587) | 30.70 | 8.48 | 31.16 | 7.89 | 9.16 (2.48 × 10−3) |
| Digit symbol (n=16 566;n=2566) | 72.32 | 17.32 | 71.59 | 16.21 | 1.47 (2.25 × 10−1) |
| Mill Hill vocabulary (n=16 456;n=2563) | 30.11 | 4.72 | 31.21 | 4.793 | 1.70 (1.92 × 10−1) |
| Verbal fluency (n=16 553;n=2575) | 39.62 | 11.67 | 40.40 | 11.91 | 13.53 (2.35 × 10−4) |
| Clinical and trait-related features | |||||
| Psycholog distress (GHQ) | 14.93 | 7.55 | 22.70a | 12.62 | 1797.00 (<1.00 × 10−100) |
| Neuroticism | 3.46 | 2.94 | 6.46a | 3.32 | 2155 (<1.00 × 10−100) |
| PRS measure (measures scaled) | |||||
| SCZ | −0.02 | 1.00 | 0.10 | 1.02 | 24.00 (9.69 × 10−7) |
Abbreviations: GHQ, General Health Questionnaire; GS:SFHS, Generation Scotland: Scottish Family Health Study; MDD, major depressive disorder; PRS, polygenic risk score; SCZ, schizophrenia.
a
Sample size as indicated unless otherwise specified in descriptive variable column, numbers for controls and MDD, respectively.
Controlled for age, sex, four-multidimensional scaling ancestry components and relatedness.