Table 1. Description of experimental groups and behavioral data.
|
TPH2 GG homozygotes |
TPH2 T allele carriers |
Statistics |
|||||
|---|---|---|---|---|---|---|---|
| Low impulsive (n=43) | High impulsive (n=21) | Low impulsive (n=21) | High impulsive (n=17) | Fgenotyp | Fimpulsivity | FgeneXimp | |
| Age (years) | 24.0 ±2.0 | 22.9 ±1.9 | 24.2 ±2.0 | 23.8 ±1.6 | 2.0 | 3.3 | 0.8 |
| Main behavioral parameters | |||||||
| Premature responses (no) | 0.2 ±0.5 | 2.5 ±0.7 | 0.5 ±0.5 | 2.8 ±1.7 | 0.7 | 124.8** | 1.1 |
| Accuracy (% correct) | 92.1±0.8 | 89.5±1.1 | 90.8±1.1 | 91.1±1.2 | 0.1 | 0.6 | 1.7 |
| Motivation index (bl2–bl1) | 0.03±.01 | 0.04±.01 | 0.03±.01 | 0.05±.01 | 1.0 | 2.7 | 0.5 |
| Descriptives of impulsivity | |||||||
| WRI | 1.3±1.5 | 1.7±1.8 | 1.2±1.4 | 1.6±1.6 | 0.06 | 1.1 | 0.01 |
| ADHD-CL | 5.7±3.9 | 7.2±4.7 | 5.8±4.4 | 6.4±5.9 | 0.1 | 1.2 | 0.2 |
| Behavioral data | |||||||
| RT_bl1 (ms) | 381±5 | 371±7 | 376±7 | 395±7 | 2.7 | 0.3 | 5.2* |
| RT_bl2 (ms) | 360±5 | 347±8 | 355±8 | 358±9 | 0.2 | 0.9 | 1.3 |
| win_0.1 (no) | 26.6±1.2 | 24.1±1.7 | 24.5±1.7 | 23.2±1.9 | 0.7 | 2.7 | 0.1 |
| win_1.0 (no) | 27.6±1.8 | 31.2±2.6 | 30.1±2.6 | 34.1±2.9 | 1.1 | 3.9 | 0.0 |
| Total win (Euro) | 11.2±3.0 | 16.2±4.3 | 15.5±4.3 | 21.5±4.7 | 1.3 | 2.5 | 0.1 |
| RT_reward presentation | 381±6 | 368±9 | 372±9 | 380±10 | 0.5 | 0.2 | 1.6 |
Abbreviations: ADHD, attention-deficit/hyperactivity disorder; ADHD-CL: ADHD checklist; bl1: baseline run 1; bl2: basline run 2; FDR, false discovery rate; gene, factor genotype; imp, factor impulsivity; RT, reaction time; WRI, Wender-Reimherr-Interview; win_0.1: win of 0.1 Euro; win_1.0: win of 1 Euro.
*P<0.05 FDR-corrected for multiple comparisons; **P<0.01 FDR-corrected for multiple comparisons.
Scores are reported as mean±s.e.