Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Main branches of the kynurenine pathway. The enzyme indoleamine 2,3 deoxygenase (IDO), which converts tryptophan to kynurenine is upregulated by pro-inflammatory cytokines. Each box represents a metabolite resulting from the oxidation of tryptophan. The black italicized text shows the enzymes that catalyze select steps in the metabolic pathway. NMDA, N-methyl-d-aspartate.
