Table 1.
Novel Loci Significantly Associated With CAD
| Lead Variant | Locus | Locus Name | A1/2 (Freq) | Discovery |
Replication |
Meta-Analysis |
Known Associations With Lead Variant | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases/Control Subjects | OR (95% CI) | p Value | Cases/Control Subjects | OR (95% CI) | p Value | OR (CI 95%) | p Value | |||||
| rs1801251 | 2q37 | KCNJ13-GIGYF2 | A/G (0.35) | 42,332/78,229 | 1.06 (1.04–1.08) | 1.46 × 10−8 | 30,528/42,521 | 1.03 (1.01–1.06) | 0.007 | 1.05 (1.03–1.06) | 1.48 × 10−9 | — |
| rs3130683 | 6p21 | C2 | T/C (0.86) | 39,494/72,267 | 1.09 (1.06–1.13) | 7.87 × 10−8 | 30,450/42,485 | 1.09 (1.05–1.14) | 2.97 × 10−5 | 1.09 (1.07–1.12) | 1.04 × 10−11 | — |
| rs11042937 | 11p15 | MRVI1-CTR9 | T/G (0.49) | 42,335/78,234 | 1.05 (1.03–1.07) | 3.21 × 10−8 | 30,533/42,527 | 1.03 (1.00–1.05) | 0.019 | 1.04 (1.03–1.06) | 1.18 × 10−8 | Bipolar disorder and schizophrenia |
| rs11172113 | 12q13 | LRP1 | C/T (0.41) | 42,335/78,234 | 1.06 (1.04–1.08) | 1.78 × 10−8 | 28,503/36,433 | 1.06 (1.03–1.08) | 1.16 × 10−6 | 1.06 (1.04–1.07) | 9.25 × 10−14 | Migraine, pulmonary function |
| rs11057830 | 12q24 | SCARB1 | A/G (0.15) | 42,331/78,237 | 1.09 (1.06–1.11) | 3.69 × 10−10 | 20,395/30,592 | 1.07 (1.03–1.11) | 0.0003 | 1.08 (1.06–1.10) | 4.61 × 10−13 | Vitamin E level |
| rs1800775 | 16q13 | CETP | C/A (0.51) | 38,810/62,756 | 1.06 (1.04–1.08) | 2.21 × 10−8 | 22,445/32,148 | 1.03 (1.00–1.05) | 0.032 | 1.04 (1.03–1.06) | 9.83 × 10−9 | HDL cholesterol |
A1/2 = allele 1/allele 2; CAD = coronary artery disease; CI = confidence interval; freq = frequency of allele 1; HDL = high-density lipoprotein; OR = odds ratio for disease for carriers of allele 1.