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Effect of brain expression of transgenic Cmah on sensitivity to a Neu5Gc-binding toxin. SubAB toxin (2 μg/mouse) was intranasally administered to 5–7-month-old female mice. The survival rate was plotted. Dashed line, control (wild-type or Cmah transgene-positive (no Cre)); solid line, NCmahTg mice. n = 8 (control) or 7 (NCmahTg) in two independent experiments.
