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. 2017 Jan 3;292(7):2956–2965. doi: 10.1074/jbc.M116.765990

FIGURE 5.

FIGURE 5.

Golgin45 acts as molecular glue promoting the oligomerization of GRASP55 through PDZ2 domain. A, oligomerization of PDZ2 domain of GRASP55 upon Golgin45 binding in the crystal of the complex. The Golgin45 peptides are shown with a stick model colored green. The PDZ2 domains of GRASP55 are shown with different colors. B, the PDZ2-PDZ2 dimer interface of GRASP55 (1–215). The two neighboring molecules are colored yellow and teal, respectively, and relevant tyrosine 196 and 198 are shown with a stick model. C, detailed interactions between Golgin45 C-terminal peptide with neighboring PDZ2 domains of GRASP55. The residues involved in the interaction are shown with a stick model. Golgin45 peptide is colored green, whereas the three different PDZ2 domains of GRASP55 are colored yellow, blue, and teal, respectively.