FIGURE 1.

Immunohistochemical staining showing high level expression of CUL4A and CUL4B in lung cancer. Representative staining of CUL4A (A–E) or CUL4B (F–J) in squamous cell carcinoma, adenocarcinoma, large cell lung carcinoma, small cell lung carcinoma, and para-carcinoma tissue is shown. K and L, CUL4A and CUL4B are both expressed at significantly higher levels in cancer tissue than that in the corresponding para-carcinoma of all subtypes of lung cancer (p < 0.001). Images in A–J are at 20 × 10 (=200) magnification, and insets are at 40 × 10 (=400) magnification, Bar, 50 μm. ***, significant p values (<0.001).