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. 2017 Feb 15;9(2):50–61. doi: 10.4251/wjgo.v9.i2.50

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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.

Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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High-resolution anoscopy of representative examples of anal intraepithelial lesions. A: Low grade AIN lesion after acetic acid application with representative acetowhitening; B: Low grade AIN lesion after application of Lugol’s iodine with brown area representing normal uptake by glycogenated cells, and “mustard” colored area representing negative uptake and suggestive of dysplasia; C: High grade AIN seen after application of acetic acid and the dense acetowhite change; D: High grade AIN with concern for invasion; E: External/perianal high grade AIN after application of acetic acid; F: High grade AIN with concern for invasion. Reproduced with permission[85]. AIN: Anal intraepithelial neoplasia.