Table 1. Demographic characteristics and summary of neuropsychologic test.
| Healthy Controls (n = 34) | Pre-treatment (n = 31) | Post-treatment (n = 31) | P-values |
||
|---|---|---|---|---|---|
| Mean(SD) | Mean(SD) | Mean(SD) | Pre vs. Posta | HC vs. Postb | |
| Age at Baseline (years) | 46.29 (4.09) | 47.10 (4.53) | NA | 0.456 | NA |
| Education (years) | 11.21 (2.09) | 10.65 (2.36) | NA | 0.313 | NA |
| Breast cancer stage | |||||
| II | NA | 10 | NA | NA | NA |
| III | NA | 17 | NA | NA | NA |
| Inter-scan interval (days) | NA | NA | 166.61 (4.46) | NA | NA |
| Fatigue | 19.82 (3.87) | 21.19 (3.02) | 24.71 (3.12) | <0.001* | <0.001* |
| HAMA | 3.97 (1.22) | 5.19 (1.05) | 4.23 (0.96) | 0.003 | 0.354 |
| HAMD | 4.38 (1.28) | 4.94 (0.93) | 4.52 (1.24) | 0.114 | 0.670 |
| MoCA | 25.50 (1.93) | 24.74 (2.22) | 25.39 (2.33) | 0.299 | 0.832 |
| Attention/concentration | |||||
| Digit Span (forward) | 6.12 (1.27) | 5.74 (1.24) | 5.61 (1.02) | 0.670 | 0.085 |
| Digit Span (backward) | 5.24 (1.10) | 4.87 (1.09) | 4.16 (0.86) | 0.010 | <0.001* |
| Stroop Color test (sec) | 14.43 (4.17) | 15.16 (3.25) | 15.11 (3.45) | 0.955 | 0.483 |
| Trailmaking A (sec) | 52.88 (9.22) | 53.63 (9.51) | 56.64 (8.14) | 0.175 | 0.087 |
| Memory (AVLT) | |||||
| Immediate Recall | 11.44 (1.76) | 11.13 (1.73) | 10.90 (1.51) | 0.607 | 0.193 |
| Delayed Recall | 10.56 (1.93) | 10.23 (1.93) | 8.84 (1.61) | 0.013 | <0.001* |
| Recognition | 9.62 (2.16) | 9.58 (1.84) | 7.87 (1.91) | 0.005 | 0.001* |
| Executive function | |||||
| Trailmaking B (sec) | 97.02 (9.85) | 96.68 (9.15) | 102.38 (10.36) | 0.016 | 0.036 |
| Stroop Word test (sec) | 17.43 (2.47) | 18.38 (3.78) | 22.20 (6.19) | 0.010 | <0.001* |
| Stroop Interference test (sec) | 30.98 (8.38) | 31.98 (7.96) | 36.82 (9.44) | 0.022 | 0.010 |
| Verbal fluency | 13.15 (2.12) | 12.87 (1.46) | 12.26 (1.88) | 0.178 | 0.080 |
Abbreviations: SD, standard deviation; HC, Healthy Controls; HAMA, Hamilton Anxiety Rating Scale; HAMD, Hamilton Depression Rating Scale; MoCA, Montreal Cognitive Assessment Test; AVLT: Auditory Verbal Learning Test.
aPaired t-tests.
bIndependent two-sample t-tests.
*Indicates significance at FDR corrected for multiple comparisons.