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. 2017 Feb 17;7:42938. doi: 10.1038/srep42938

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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When TNF-α was withdrawn, SA-β-Gal activity (A), G1 cell cycle arrest (B) and the expression of senescence markers (C) in the TNF-α withdrawal group were still increased compared with those in the control group. The data are expressed as the mean ± SD (n = 3). *Indicates a significant difference (p < 0.05) compared with the control group. ^#Indicates a significant difference (p < 0.05) between the TNF-α group and the TNF-α withdrawal group.