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. 2017 Feb 17;7:42589. doi: 10.1038/srep42589

Figure 2. ABHD5 G328 is essential for ATGL activation.

Figure 2

(a) Homology analysis of vertebrate ABHD4 and ABHD5 paralogs. Identical residues in all vertebrate homologs of each protein are indicated in bold, based on analysis of proteins in the NCBI database as of May 2016. Asterisks indicate ABHD5 identical residues not conserved between ABHD4 and ABHD5. (b) Chimera C S332G activates lipolysis in Cos7 cells. **p < 0.01. (c) ABHD5 G328S does not activate lipolysis. Values are means ± SEM from three independent experiments. (d) Representative images of ABHD mutant transfected Cos7 cells. Scale bar = 10 μm.