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. 2017 Feb 17;7:42589. doi: 10.1038/srep42589

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Copyright © 2017, The Author(s)

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(a) ABHD4 N303R/S332G activates ATGL-dependent lipolysis in transfected Cos7 cells. (b) ABHD5 R299N does not activate lipolysis. (c) Representative images of ABHD mutant transfected Cos7 cells. Scale bar = 10 μm. (d) Human ABHD4 D290R/S319G activates lipolysis. (e) Partially purified ABHD4 N303R/S332G activates lipolysis in artificial LDs. Inset shows strep tag immunoblot of relative ABHD protein levels in assay. For (a,b,d,e), values are means ± SEM from three independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001.