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. 2017 Feb 17;7:42846. doi: 10.1038/srep42846

Figure 8. PEDF mediated macrophage polarization via MAPKs and Notch1 pathway.

Figure 8

(a) Time curve of MAPKs, including p38MAPK, JNK and ERK phosphorylation and Notch1 accumulation induced by hypoxia in BMDMs. (b) Phosphorylation of p38MAPK, JNK, ERK and accumulation of Notch1 in BMDMs induced by hypoxia pretreated with or without PEDF. (c) Quantitation of iNOS and Arg-1 expression in BMDMs induced by hypoxia pretreated with p38MAPK inhibitor SB202190, JNK inhibitor SP600125, ERK inhibitor U0126 and Notch1 inhibitor DAPT(GSI-IX). (d) Phosphorylation of p38MAPK, JNK, ERK and accumulation of Notch1 in the macrophages isolated from the retinal of normal and OIR mice treated with or without PEDF. All data are representative of three independent experiments with n = 5 per group and are means ± SEM.