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. 2017 Feb 17;7:41921. doi: 10.1038/srep41921

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(a) One cycle of Breakage-Fusion-Bridge. A dicentric chromosome breaks after each centromere is pulled to an opposite pole. End processing and fold-back DNA synthesis create a hairpin-capped chromosome. Replication of the hairpin-capped chromosome generates an isodicentric chromosome with the inverted duplication of ERBB2 genes.(b) At (iso) dicentric breakage, each daughter cell receives an unequal amount of genetic material. (c) Copy number heterogeneity generated by BFB cycles. Each cell has an intact and a rearranged chromosome.