Table 4.

Distribution of RET Germline Mutations^a Outside Europe^b

		China	China	India	Iran	China	Korea
		S (17)	S (18)	S (19)	M (20)	(21)	M (22)
Exon	RET mutation	n (%)	n (%)	n (%)	n (%)	n (%)	n (%)
5	p.V292M	0	1 (9)	0	0	0	0
8	p.C515S	0	0	0	0	0	0
8	p.G533C	0	0	0	0	0	0
10	p.C609R/G/F/S/Y	0	0	2 (13)	0	0	0
10	p.C611R/G/F/S/W/Y	0	0	0	1 (9)	0	0
10	p.C618R/G/F/S/Y	2 (20)	1 (9)	1 (7)	1 (9)	0	3 (23)
10	p.C620R/G/F/S/W/Y	0	0	0	0	0	0
11	p.C630R/F/Y	0	0	0	1 (9)	0	0
11	p.D631Y	0	0	0	0	0	0
11	p.C634R/G/F/S/W/Y	6 (60)	8 (73)	9 (60)	6 (55)	15 (75)	10 (77)
11	p.K666E	0	0	0	0	0	0
12	p.A750P	0	0	0	0	0	0
13	p.E768D	0	0	0	0	0	0
13	p.L790F	1 (10)	1 (9)	0	0	0	0
14	p.V804L/M	0	0	1 (7)	1 (9)	0	0
14	p.I852M	0	0	0	0	0	0
15	p.A883F/T	0	0	0	0	0	0
15	p.S891A	0	0	0	0	0	0
15	p.S904F	0	0	0	0	0	0
16	p.R912P	0	0	0	0	0	0
16	p.M918T	1 (10)	0	2 (13)	1 (9)	5 (25)	0
Total		10 (100)	11 (100)	15 (100)	11 (100)	20 (100)	13 (100)

Due to rounding up, not all sums of the numbers fit.

^aSequence changes classified as pathogenic in the ARUP database July 1, 2016 (30).

^bIncluding series with a minimum of 10 European RET families ((25,38,39) excluded), a minimum of exons 10–11 and 13–16 tested ((23,24) excluded), and specifying familial prevalence.

S, single center; M, multicenter; n, number of families.