FIG. 4.

Biochemical map showing metabolic perturbations in urine from a patient diagnosed with citrullinemia. Red circles indicate biochemicals with positive Z scores and blue circles indicate biochemicals with negative Z scores. The diameters of the circles indicate the magnitude of the Z score. Pink circles represent biochemicals with Z score of 1.5 ≤ Z < 2.0, and light blue circles represent biochemicals with −2.0 < Z ≤ −1.5. Black circles represent other biochemicals in the pathway detected in the urine sample, but had Z scores of −1.5 < Z < 1.5. Gray circles represent biochemicals in the library but not detected. White circles are biochemicals not detected on the mass spectrometry platform.