Table 1. Putative functional epigenetic drivers exhibit lower connectivity than their functional SCN counterparts.
| P-values of one-tailed Wilcoxon test comparing connectivity | |||||
|---|---|---|---|---|---|
| COAD | HyperM | HypoM | Amplification | Deletion | |
| HyperM | NA | 0.95 | 1 | 1 | |
| HypoM | 0.05 | NA | 1 | 1 | |
| Amplification | 6e-13 | 5e-07 | NA | 0.921 | |
| Deletion | 1e-14 | 1e-08 | 0.079 | NA | |
| HNSC | HyperM | HypoM | Amplification | Deletion | |
| HyperM | NA | 0.991 | 1 | 1 | |
| HypoM | 0.009 | NA | 1 | 1 | |
| Amplification | 7e-14 | 1e-09 | NA | 0.578 | |
| Deletion | 3e-15 | 2e-11 | 0.423 | NA | |
| BLCA | HyperM | HypoM | Amplification | Deletion | |
| HyperM | NA | 0.97 | 1 | 1 | |
| HypoM | 0.03 | NA | 1 | 1 | |
| Amplification | 4e-12 | 2e-07 | NA | 0.153 | |
| Deletion | 4e-08 | 1e-04 | 0.848 | NA | |
| BRCA | HyperM | HypoM | Amplification | Deletion | |
| HyperM | NA | 0.729 | 1 | 1 | |
| HypoM | 0.272 | NA | 1 | 1 | |
| Amplification | 1e-10 | 4e-09 | NA | 0.034 | |
| Deletion | 2e-05 | 2e-04 | 0.966 | NA | |
| KIRC | HyperM | HypoM | Amplification | Deletion | |
| HyperM | NA | 0.734 | 1 | 1 | |
| HypoM | 0.266 | NA | 1 | 1 | |
| Amplification | 6e-06 | 4e-05 | NA | 0.999 | |
| Deletion | 6e-14 | 1e-12 | 9e-04 | NA | |
| LIHC | HyperM | HypoM | Amplification | Deletion | |
| HyperM | NA | 0.65 | 1 | 1 | |
| HypoM | 0.351 | NA | 1 | 1 | |
| Amplification | 4e-13 | 3e-09 | NA | 0.51 | |
| Deletion | 1e-10 | 8e-08 | 0.491 | NA | |
| LUSC | HyperM | HypoM | Amplification | Deletion | |
| HyperM | NA | 1 | 1 | 1 | |
| HypoM | 3e-04 | NA | 1 | 0.991 | |
| Amplification | 2e-12 | 1e-04 | NA | 0.035 | |
| Deletion | 5e-10 | 0.009 | 0.965 | NA | |
| LUAD | HyperM | HypoM | Amplification | Deletion | |
| HyperM | NA | 0.247 | 1 | 1 | |
| HypoM | 0.754 | NA | 1 | 1 | |
| Amplification | 8e-14 | 2e-13 | NA | 0.294 | |
| Deletion | 3e-10 | 2e-10 | 0.707 | NA | |
| THCA | HyperM | HypoM | Amplification | Deletion | |
| HyperM | NA | 0.254 | 0.849 | 0.938 | |
| HypoM | 0.757 | NA | 1 | 1 | |
| Amplification | 0.155 | 3e-04 | NA | 0.98 | |
| Deletion | 0.064 | 1e-06 | 0.02 | NA | |
| UCEC | HyperM | HypoM | Amplification | Deletion | |
| HyperM | NA | 0.998 | 1 | 1 | |
| HypoM | 0.002 | NA | 1 | 1 | |
| Amplification | 6e-12 | 6e-06 | NA | 0.611 | |
| Deletion | 4e-14 | 5e-07 | 0.39 | NA | |
Table lists one-tailed Wilcoxon rank sum test P-values comparing the connectivity (degree) distribution of the top ranked 100 genes in each molecular alteration group between each other, and for each of 10 TCGA cancer types. For each cancer type, the alternative hypothesis being tested is that the connectivity of the gene-class in the column is smaller than that of the gene class indicated in the row.