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. 2016 Sep 30;45(2):711–725. doi: 10.1093/nar/gkw877

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 9. — Model for the role of BCCIP in BRCA2-DSS1-RAD51-mediated HR. DSS1 targets the BRCA2-DSS1-RAD51-BCCIPβ complex to RPA-coated ssDNA. DSS1 helps BRCA2 displace RPA from the ssDNA to facilitate nucleation of RAD51 onto the ssDNA forming the presynaptic filament. The active RAD51 filament hydrolyzes bound ATP (T) leading to a condensed and inactive ADP-bound RAD51 filament (D). BCCIPβ promotes the release of ADP from the inactive RAD51 filament, allowing ATP to bind reactivating the RAD51 presynaptic filament. Calcium inhibits ATP hydrolysis by RAD51 to help maintain the RAD51 filament in an active form.