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. 2016 Oct 5;45(2):631–642. doi: 10.1093/nar/gkw889

Figure 7.

Figure 7.

The corA leader RNA controls three steps of Rho-dependent transcription termination. Once RNAP (light blue) begins transcribing the corA gene, cytoplasmic signal(s) can influence whether the corA leader RNA adopts the stem-loop B conformation or the stem-loops C+D conformatiion. The stem-loop B conformation presents an accessible rut site (dark blue), whereas stem-loops C+D sequester nucleotides specifically recognized by Rho (yellow). Stem-loops C+D also reduce the efficiency of RNAP pausing at U240 (red star). Stem-loop E (orange), whose formation is independent of stem-loops B versus C+D, prevents Rho from accessing RNAP complexes paused at U192 (green star), thus promoting termination at downstream sites. Black lines represent RNA and grey lines represent DNA.