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. 2016 Dec 21;4(1):e1248273. doi: 10.1080/21690707.2016.1248273

Figure 2.

Figure 2.

Multifactorial disorder profiles of 7 major subunits of human Hb. Evaluating intrinsic disorder propensity by series of per-residue disorder predictors. Disorder profiles generated by PONDR® VSL2, IUPred_short, PONDR® FIT, and IUPred_long are shown by black, red, green, and yellow lines, respectively. Dark red dashed line shows the mean disorder propensity calculated by averaging disorder profiles of individual predictors. Light green shadow around the PONDR® FIT curves shows error distribution. In these analyses, the predicted intrinsic disorder scores above 0.5 are considered to correspond to the disordered residues/regions, whereas regions with the disorder scores between 0.2 and 0.5 are considered flexible. Disorder profiles for the α-, β-, γ1-, γ2-, δ-, ε-, and ζ-subunits are shown in plots A, B, C, D, E, F, and G, respectively. H. Aligned PONDR® VSL2-based disorder profiles for the α-, β-, γ1-, γ2-, δ-, ε-, and ζ-subunits of human Hb. Outputs for the individual subunits were aligned using results of multiple sequence alignment shown in Fig. 1A. Gaps in the individual disorder profiles correspond to the deletions.