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. 2015 Jun 3;3(1):e1056906. doi: 10.1080/21690707.2015.1056906

Figure 2.

Figure 2.

Domain architecture and sequence alignment of FOXO transcription factors. The domain architecture of FOXO3a contains a well-folded Forkhead (FH) DNA-binding domain, and 3 conserved regions, CR1-CR3. Sequence alignments of CR1, CR2C and CR3 are shown with conserved residues highlighted in gray boxes. The solution structure of FH (PDB: 2K86) is shown above and the secondary structure elements are labeled. The structures of 2 states of CR2C and CR3 bound to the KIX domain of CBP (PDB: 2LQI and 2LQH) are shown below, with CR2C colored yellow and CR3 colored red.