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. 2017 Feb 15;34(4):890–905. doi: 10.1089/neu.2016.4508

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© Laura B. Tucker, et al. 2016; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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FIG. 2. — Open field (OF) behavior following controlled cortical impact (CCI). There was a main effect of sex on activity in the OF, with females (B) ambulating greater distances than males (A). Severe CCI, but not mild CCI, increased the distance traveled in the arena compared with sham controls on all post-injury days (A and B, dashed lines). Analysis of center zone activity (C and D), expressed as a function of total activity, suggested that mice with severe, but not mild traumatic brain injury (TBI) were anxious on all post-injury days tested compared with sham controls. The asterisk (*) shown in B represents the main effect of sex on the distance traveled in the arena (female > male); the pound sign (#) represents the effect of severe CCI on distance traveled (severe CCI > sham) and center activity (severe CCI < sham).