FIG. 3.

Anxiety-like behaviors assessed in a light-dark box (LDB). During the first exposure to the LDB (day 2 following injury; A), female mice were overall more active than male mice; however, all mice ambulated equivalent distances on day 21 after injury (B). On day 2 following CCI, mice that had sustained the severe level of injury spent less time in the dark chamber than sham-control mice or mice that had sustained mild CCI (C). On day 21 after injury (D), female mice that had sustained mild CCI spent less time in the darkened chamber than females with the severe injury. The asterisk (*) indicates an effect of sex, and the pound sign (#) denotes a significant effect of injury.