Fig. 3. A schematic overview of the enantioconvergent hydrolysis of different enantiomers of an epoxide substrate to give the same product diol. In the present case, StEH1-catalyzed styrene oxide hydrolysis proceeds primarily through attack at C-1 for the (S)-enantiomer, and C-2 for the (R)-enantiomer), in contrast to the non-enzymatic hydroxide-catalyzed hydrolysis, where hydroxide addition at each of the two carbon atoms occurs with almost equal rates.¹⁹ .