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. Author manuscript; available in PMC: 2017 Apr 15.
Published in final edited form as: J Immunol. 2016 Mar 7;196(8):3411–3420. doi: 10.4049/jimmunol.1500906

Figure 2.

Figure 2

Inflammasome activation and IL-1β inhibit fetal lung airway morphogenesis. (A–D). LPS did not inhibit airway branching in E15 explants from Il1b−/− mice (n = 49–56) or Nlrp3−/− mice (n = 44–50). (E–H). Treating E15 fetal lung explants from C57BL/6 mice with the caspase-1 inhibitor Ac-Tyr-Val-Ala-Asp-CHO (YVAD, 1 µM) inhibited IL-1β release (H) and protected fetal lung explants from the effects of LPS (G). (*P < 0.05, #P < 0.01, n = ≥ 16 explants from 3 different litters).