Table 2.

Pharmacokinetic parameters after single- and multi-dose intragastric administration of 3.75 mg/kg of ponatinib to rats $(\overline{x}\pm s,n=6)$

Parameters	Single dose	Multi-dose
C max (μg/L)	129.46 ± 37.57	188.82 ± 55.69
T max (h)	10.00 ± 2.19	6.67 ± 3.01
T 1/2 (h)	11.29 ± 1.46	10.92 ± 1.56
MRT (h)	16.77 ± 1.91	21.34 ± 1.27*
AUC0–∞ (μg h/L)*	2301.84 ± 787.10	5479.41 ± 757.07*
V (L/kg)	28.91 ± 9.47	10.85 ± 1.49
CL (L/kg/h)	1.79 ± 0.61	0.70 ± 0.11

* Significant difference from to the single-dose group (p < 0.05)