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. 2017 Feb 13;11:393–406. doi: 10.2147/DDDT.S103505

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© 2017 Rajabalaya et al. This work is published and licensed by Dove Medical Press Limited

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Drug solubilization within the small intestine.

Notes: The drugs are localized in lipid droplets possessing multiple layers of LCs on their surface. The layers are then shed from the droplet, forming small unilamellar or multilamellar vesicles. These vesicles are then solubilized into micelles and mixed micelles. Further solubilization would then promote lipid absorption across the intestinal mucosa.

Abbreviations: BS, bile salt; DG, diglycerol; FA, fatty acids; LC, liquid crystal; MG, monoglycerol; PL, phospholipid.