Table 2.

Logistic Regression for Oral Clefts Including Interactions between First-Trimester Maternal Smoking and Pre-Pregnancy BMI

Cleft Status	Smoking			BMI├			Smoking × BMI├
	OR†	95% CI		OR†	95% CI		OR†	95% CI		P-Value
Isolated and non- Isolated Clefts
Any Cleft	2.18	1.49	3.17	1.13	1.05	1.21	0.84	0.72	0.97	0.02
Cleft lip Only	3.03	1.53	6.00	1.09	0.96	1.24	0.75	0.57	0.99	0.04
Cleft Lip with     Palate	1.84	1.11	3.04	1.13	1.02	1.24	0.90	0.74	1.09	0.28
Cleft Palate Only	2.23	1.27	3.93	1.17	1.05	1.29	0.82	0.65	1.02	0.07
Isolated Clefts
Any Cleft	2.26	1.51	3.36	1.11	1.03	1.19	0.84	0.72	0.98	0.03
Cleft lip Only	3.15	1.56	6.36	1.07	0.94	1.23	0.76	0.57	1.01	0.06
Cleft Lip with     Palate	1.52	0.89	2.60	1.07	0.97	1.19	0.98	0.79	1.21	0.84
Cleft Palate Only	3.20	1.66	6.14	1.18	1.05	1.32	0.71	0.55	0.92	0.01

Notes:

^†Multivariable logistic regression model adjusted for, maternal education (less than high school degree versus higher education), maternal age (≤18, 19–25, 26–30, 31–35, 36–49yrs), any alcohol use (Yes/No) and folic acid use(Yes/No) as well as study dummy variables. A separate regression is estimated for each cleft group.

^├BMI is expressed in 10 units.