Table 2.
Increased positive functional connectivities in patients with insomnia
| COI | Network | z value in patients with insomnia | z value in healthy controls | Two-sample 2-tailed t-tests | P-value |
|---|---|---|---|---|---|
| R precuneus-L supramarginal gyrus | DMN-SMN | 0.43±0.21 | 0.30±0.26 | 2.64 | 0.0096 |
| R precuneus-R olfactory cortex | DMN-SMN | 0.29±0.18 | 0.19±0.17 | 2.75 | 0.0070 |
| L parahippocampal gyrus-L orbital part of middle frontal gyrus | DMN-ORB | 0.22±0.17 | 0.12±0.22 | 3.22 | 0.0017 |
| L hippocampus-L orbital part of superior frontal gyrus | DMN-ORB | 0.17±0.19 | 0.06±0.19 | 3.82 | 0.0002 |
| L insula lobe-L orbital part of middle frontal gyrus | SN-ORB | 0.18±0.23 | 0.06±0.23 | 2.72 | 0.0076 |
| L insula lobe-R rectus gyrus | SN-ORB | 0.16±0.23 | 0.04±0.21 | 2.68 | 0.0086 |
| L anterior cingulate gyrus-L olfactory cortex | SN-SMN | 0.36±0.16 | 0.26±0.20 | 2.83 | 0.0057 |
| R insula lobe-L olfactory cortex | SN-SMN | 0.18±0.18 | 0.08±0.20 | 2.98 | 0.0036 |
| R anterior cingulate gyrus-L olfactory cortex | SN-SMN | 0.31±0.17 | 0.21±0.21 | 2.80 | 0.0061 |
| R amygdala-R cerebellum 10 | AN-CER | 0.15±0.21 | 0.03±0.23 | 2.66 | 0.0091 |
| R amygdala-L supramarginal gyrus | AN-SMN | 0.30±0.22 | 0.19±0.19 | 2.66 | 0.0090 |
| R orbital part of median superior frontal gyrus-R cerebellum 10 | ORB-CER | 0.21±0.19 | 0.09±0.23 | 2.70 | 0.0082 |
| L orbital part of superior frontal gyrus-R cerebellum 10 | ORB-CER | 0.21±0.21 | 0.07±0.20 | 3.27 | 0.0014 |
| L orbital part of superior frontal gyrus-R cerebellum 7b | ORB-CER | 0.28±0.24 | 0.12±0.29 | 3.36 | 0.0011 |
| L rectus gyrus-R cerebellum 10 | ORB-CER | 0.23±0.21 | 0.10±0.20 | 2.69 | 0.0083 |
| R rectus gyrus-R cerebellum 10 | ORB-CER | 0.26±0.22 | 0.10±0.21 | 2.67 | 0.0088 |
| R rectus gyrus-R cerebellum 7b | ORB-CER | 0.43±0.18 | 0.30±0.20 | 3.03 | 0.0030 |
| R rectus gyrus-L olfactory cortex | ORB-SMN | 0.27±0.22 | 0.13±0.28 | 2.67 | 0.0088 |
| L putamen-R rectus gyrus | SUB-ORB | 0.23±0.18 | 0.13±0.16 | 2.67 | 0.0088 |
| R putamen-L olfactory cortex | SUB-SMN | 0.21±0.16 | 0.11±0.18 | 2.77 | 0.0067 |
| L putamen-R olfactory cortex | SUB-SMN | 0.26±0.17 | 0.18±0.15 | 2.73 | 0.0075 |
| L supramarginal gyrus-R cerebellum 4.5 | SMN-CER | 0.39±0.23 | 0.27±0.25 | 2.63 | 0.0098 |
| L olfactory cortex-L cerebellum 7b | SMN-CER | 0.17±0.17 | 0.07±0.21 | 2.77 | 0.0067 |
| R supplementary motor area-R olfactory cortex | SMN-SMN | 0.28±0.16 | 0.19±0.17 | 3.13 | 0.0023 |
| R olfactory cortex-L superior temporal gyrus | SMN-SMN | 0.29±0.17 | 0.18±0.18 | 2.73 | 0.0075 |
| R olfactory cortex-L supramarginal gyrus | SMN-SMN | 0.17±0.19 | 0.07±0.16 | 2.75 | 0.0070 |
| R olfactory cortex-L paracentral lobule | SMN-SMN | 0.27±0.17 | 0.18±0.16 | 2.73 | 0.0075 |
| R superior parietal gyrus-R cerebellum 7b | CEN-CER | 0.36±0.35 | 0.17±0.35 | 2.65 | 0.0094 |
Abbreviations: COI, connectivity of interest; R, right; L, left; DMN, default mode network; SMN, sensory-motor network; ORB, orbital part of frontal lobe; SN, salience network; AN, affective network; CER, cerebellum; SUB, subcortical regions; CEN, central-executive network.