Figure 3.
Blocking of GABAA receptors in the ACC reduced mechanical threshold. (a) The effects of the GABAA antagonist, bicuculline on McN-A-343(189 pmol)-induced antinociceptive effect (McN-A-343, n = 7; McN-A-343 + bicuculline100 pmol, n = 5; McN-A-343 + bicuculline 150 pmol, n = 6). (b) The local injection of the GABAA receptors antagonist, bicuculline (100 or 150 pmol) into the ACC decreased mechanical thresholds (saline, n = 4; bicuculline 100 pmol, n = 5; 150 pmol, n = 7). All values are means ± S.E.M. *P < 0.05 vs. 0 min, **P < 0.01 vs. 0 min, #P < 0.05 vs. McN-A-343 (a) or saline (c), ##i < 0.01 vs. McN-A-343 (a) or saline (c). ACC: anterior cingulate cortex