Table 2. Key mechanical and functional sites.

top sites for av. bridging score	key functional sites (Tehan et al. [23])
7x52	1x50	6x40
3x40	2x46	6x41
7x42	2x50	6x44
6x44	3x40	6x48
7x45	3x43	6x50
3x43	3x50	7x49
3x36	4x50	7x50
3x44	5x50	7x53
6x43	5x58
6x40	6x30

The first column provides the ranked list of sites with the highest mechanical bridging score averaged over all receptors of class A. The list of known key functional sites for the same class is shown in the second column. Residues present in both lists are highlighted in boldface. The list of top-scoring residues for each receptor is given in Table A in S1 Supporting Information.