Figure 2.

Genomic and metagenomic distribution of the cof genes that encode F₄₂₀ biosynthesis enzymes. The genes encoding the five known proteins specifically required for F₄₂₀ synthesis are shown, namely CofC, CofD, CofE, CofG and CofH, where CofGH represents a fusion protein. (a) Distribution of cof genes by phyla in the NCBI Reference Sequence database. (b) Distribution of cof genes in 19 publicly available metagenomes by enzyme. (c) Distribution of cof genes in 19 publicly available metagenomes by phylum of the closest BLAST hit (>60% identity).