Intracisternal BDNF produces cutaneous allodynia. Administration of 1 or 10 picograms (pg) of BDNF i.c produces cutaneous facial (A) and hindpaw (B) allodynia. Allodynia induced by BDNF at 1 pg (n=20) resolved within 72 hours, whereas that induced by 10pg (n=6) of BDNF persisted beyond 72 hours. Vehicle (n=5) i.c. showed no significant results at any time point. Facial: time F (8, 252) = 5.85, P < 0.0001, treatment F (2,252) = 31.02, P < 0.0001; Hind paw: time F (3, 64) = 4.937 P < 0.0001, treatment F (3, 64) = 60.07, P < 0.0001