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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Pain. 2016 Dec;157(12):2722–2730. doi: 10.1097/j.pain.0000000000000692

Figure 8.

Figure 8

Priming following intracisternal BDNF lasts for at least several weeks. BDNF-treated animals developed facial allodynia when given i.p SNP at 72 hours (A) (BDNF/SNP n=10, BDNF/vehicle n=8, Vehicle/Vehicle n=5, Vehicle/SNP n=5) or day 16 (B) (n=8 for all groups) post BDNF treatment. A significant attenuation of withdrawal thresholds to tactile stimuli applied to the face were observed at both 3 hours and 24 hours, whereas hindpaw responses were only significant 3 hours after 72 hour SNP administration. However, on day 16 a significant attenuation of withdrawal thresholds was observed 3 hours after SNP administration for facial and hindpaw responses. Allodynia was not observed in i.c. BDNF-treated animals given vehicle at 72 hours or day 16(. Significant (****p < 0.0001) differences among means for each group were determined one-way ANOVA followed by Bonferroni post hoc test. (A) Facial: time F (3, 64) = 8.347, P =< 0.0001, treatment F (1, 64) = 12.30, P =0.0008; Hind paw: time F (3, 96) = 1.789, P =0.1544, treatment F (3, 96) = 11.55, P < 0.0001(B)Facial: time F (3, 56 = 26.59, P < 0.0001, treatment F (1,56) = 24.15, P < 0.0001; Hind paw: time F (8, 406) = 8.027, P < 0.0001, treatment F (1, 406) = 87.69, P < 0.0001