Figure 2.

Genome-wide admixture analysis of selected Amerindian controls and mestizo HD patients from Peru relative to the 1000 Genomes Project reference samples. (a) Plotting of principal components 3 and 4 from Amerindian Peruvian individuals reveals extreme clustering by ethnicity and partial overlap with reference Peruvians from the 1000 Genomes Project. Amerindian Peruvian controls are most similar to reference Peruvians, reflecting known heterogeneity of indigenous genetic ancestry across Latin America. (b) ADMIXTURE analysis suggests a nearly exclusive indigenous ancestry among Amerindian Peruvian controls, including all Amerindian individuals with the A1 haplotype. Mestizo Peruvian HD probands show similar levels of admixture as reference Peruvians relative to Europeans from Spain and Portugal (K=5, see Supplementary Figure 1).