Skip to main content
. 2016 Dec 21;25(3):332–340. doi: 10.1038/ejhg.2016.169

Figure 4.

Figure 4

The frequency of European and Amerindian A1 HTT haplotypes differs dramatically between HD chromosomes from Caucasian Canadian patients and mestizo Peruvian patients. The A1 HTT haplotype in mestizo Peruvian HD and control chromosomes is almost exclusively the Amerindian A1 variant. In Amerindian Peruvian controls, the A1 HTT haplotype is exclusively the Amerindian A1 variant. In contrast, the Amerindian A1 haplotype variant occurs rarely in Caucasian Canadian HD chromosomes. The A1 HTT haplotype is defined by variant alleles at rs72239206 (GRCh37 chr4:g.3142661_3142664delACTT), rs149109767 (GRCh37 chr4:g.3230411_3230413delGAG), and rs362307 (GRCh37 chr4:g.3241845C>T). The Amerindian A1 variant haplotype is additionally defined by the C allele at rs12508079 (GRCh37 chr4:g.3080238T>C).